SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8(+) T cells

The functional integrity of CD8(+) T cells is tightly coupled to metabolic reprogramming, but how oxidative stress directs CD8(+) T cell metabolic fitness in the tumor microenvironment (TME) remains elusive. Here, we report that SUMO-specific protease 7 (SENP7) senses oxidative stress to maintain th...

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Detalles Bibliográficos
Autores principales: Wu, Zhongqiu, Huang, Haiyan, Han, Qiaoqiao, Hu, Zhilin, Teng, Xiao-Lu, Ding, Rui, Ye, Youqiong, Yu, Xiaoyan, Zhao, Ren, Wang, Zhengting, Zou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970670/
https://www.ncbi.nlm.nih.gov/pubmed/35143421
http://dx.doi.org/10.1172/JCI155224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970670/
https://www.ncbi.nlm.nih.gov/pubmed/35143421
http://dx.doi.org/10.1172/JCI155224

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