XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury

Hepatocellular cell death and macrophage proinflammatory activation contribute to the pathology of various liver diseases, during which XBP1 plays an important role. However, the function and mechanism of XBP1 in thioacetamide (TAA)-induced acute liver injury (ALI) remains unknown. Here, we investig...

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Detalles Bibliográficos
Autores principales: Liu, Zheng, Wang, Mingming, Wang, Xun, Bu, Qingfa, Wang, Qi, Su, Wantong, Li, Lei, Zhou, Haoming, Lu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971356/
https://www.ncbi.nlm.nih.gov/pubmed/35367811
http://dx.doi.org/10.1016/j.redox.2022.102305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971356/
https://www.ncbi.nlm.nih.gov/pubmed/35367811
http://dx.doi.org/10.1016/j.redox.2022.102305

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