Cargando…
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury
Hepatocellular cell death and macrophage proinflammatory activation contribute to the pathology of various liver diseases, during which XBP1 plays an important role. However, the function and mechanism of XBP1 in thioacetamide (TAA)-induced acute liver injury (ALI) remains unknown. Here, we investig...
Autores principales: | Liu, Zheng, Wang, Mingming, Wang, Xun, Bu, Qingfa, Wang, Qi, Su, Wantong, Li, Lei, Zhou, Haoming, Lu, Ling |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971356/ https://www.ncbi.nlm.nih.gov/pubmed/35367811 http://dx.doi.org/10.1016/j.redox.2022.102305 |
Ejemplares similares
-
TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling
por: Su, Wantong, et al.
Publicado: (2023) -
XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression
por: Wang, Qi, et al.
Publicado: (2022) -
Lactate-induced mtDNA Accumulation Activates cGAS-STING Signaling and the Inflammatory Response in Sjögren's Syndrome
por: Xu, Jiabao, et al.
Publicado: (2023) -
Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway
por: Li, Yujia, et al.
Publicado: (2022) -
Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release
por: Xu, Lei, et al.
Publicado: (2022)