Efficient targeted transgenesis of large donor DNA into multiple mouse genetic backgrounds using bacteriophage Bxb1 integrase

The development of mouse models of human disease and synthetic biology research by targeted transgenesis of large DNA constructs represent a significant genetic engineering hurdle. We developed an efficient, precise, single-copy integration of large transgenes directly into zygotes using multiple mo...

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Detalles Bibliográficos
Autores principales: Low, Benjamin E., Hosur, Vishnu, Lesbirel, Simon, Wiles, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971409/
https://www.ncbi.nlm.nih.gov/pubmed/35361849
http://dx.doi.org/10.1038/s41598-022-09445-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971409/
https://www.ncbi.nlm.nih.gov/pubmed/35361849
http://dx.doi.org/10.1038/s41598-022-09445-w

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