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Effects of cryo-EM cooling on structural ensembles

Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what extent the structural ensemble i...

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Detalles Bibliográficos
Autores principales: Bock, Lars V., Grubmüller, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971465/
https://www.ncbi.nlm.nih.gov/pubmed/35361752
http://dx.doi.org/10.1038/s41467-022-29332-2