Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation

The indoleamine 2,3-dioxygenase 1 (IDO1) metabolic circuitry, comprising the first tryptophan (Trp) catabolite L-kynurenine (Kyn) and the aryl hydrocarbon receptor (AHR), has emerged as a mechanism of cancer immune evasion. Here, we investigated the functional role of the IDO1/Kyn/AHR axis in chroni...

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Detalles Bibliográficos
Autores principales: Atene, Claudio Giacinto, Fiorcari, Stefania, Mesini, Nicolò, Alboni, Silvia, Martinelli, Silvia, Maccaferri, Monica, Leonardi, Giovanna, Potenza, Leonardo, Luppi, Mario, Maffei, Rossana, Marasca, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971515/
https://www.ncbi.nlm.nih.gov/pubmed/35371054
http://dx.doi.org/10.3389/fimmu.2022.832263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971515/
https://www.ncbi.nlm.nih.gov/pubmed/35371054
http://dx.doi.org/10.3389/fimmu.2022.832263

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