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Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles
Engineered signaling networks can impart cells with new functionalities useful for directing differentiation and actuating cellular therapies. For such applications, the engineered networks must be tunable, precisely regulate target gene expression, and be robust to perturbations within the complex...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971529/ https://www.ncbi.nlm.nih.gov/pubmed/35361767 http://dx.doi.org/10.1038/s41467-022-29338-w |