Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, driven by the BCR-ABL1 fusion oncoprotein. The discovery of orthosteric BCR-ABL1 tyrosine kinase inhibitors (TKIs) targeting its active ATP-binding pocket, such as first-generation Imatinib and second-generation Nilotinib (NIL), has pr...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Zhu, Mingsheng, Li, Mingzi, Ni, Duan, Wang, Yuanhao, Deng, Liping, Du, Kui, Lu, Shaoyong, Shi, Hui, Cai, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971931/
https://www.ncbi.nlm.nih.gov/pubmed/35370687
http://dx.doi.org/10.3389/fphar.2022.862504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971931/
https://www.ncbi.nlm.nih.gov/pubmed/35370687
http://dx.doi.org/10.3389/fphar.2022.862504

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