Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation

FBXO41 is a neuron-specific E3 ligase subunit implicated in epileptic encephalopathies. Fbxo41 null mutant (KO) mice show behavioral deficits and early lethality. Here, we report that loss of FBXO41 causes defects in synaptic transmission and brain development. Cultured Fbxo41 KO neurons had normal...

Descripción completa

Detalles Bibliográficos
Autores principales: Quadros, Ana R.A.A., Arazola, Rocío Díez, Álvarez, Andrea Romaguera, Pires, Johny, Meredith, Rhiannon M., Saarloos, Ingrid, Verhage, Matthijs, Toonen, Ruud F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971942/
https://www.ncbi.nlm.nih.gov/pubmed/35372812
http://dx.doi.org/10.1016/j.isci.2022.104069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971942/
https://www.ncbi.nlm.nih.gov/pubmed/35372812
http://dx.doi.org/10.1016/j.isci.2022.104069

Ejemplares similares