Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries

Although there have been recent transformative advances in the area of protein structure prediction, prediction of point mutations that improve protein stability remains challenging. It is possible to construct and screen large mutant libraries for improved activity or ligand binding. However, relia...

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Detalles Bibliográficos
Autores principales: Ahmed, Shahbaz, Manjunath, Kavyashree, Chattopadhyay, Gopinath, Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971944/
https://www.ncbi.nlm.nih.gov/pubmed/35247389
http://dx.doi.org/10.1016/j.jbc.2022.101785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971944/
https://www.ncbi.nlm.nih.gov/pubmed/35247389
http://dx.doi.org/10.1016/j.jbc.2022.101785

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