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Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries
Although there have been recent transformative advances in the area of protein structure prediction, prediction of point mutations that improve protein stability remains challenging. It is possible to construct and screen large mutant libraries for improved activity or ligand binding. However, relia...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971944/ https://www.ncbi.nlm.nih.gov/pubmed/35247389 http://dx.doi.org/10.1016/j.jbc.2022.101785 |