Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion

G protein-coupled receptors (GPCRs) in intestinal enteroendocrine cells (EECs) respond to nutritional, neural, and microbial cues and modulate the release of gut hormones. Here we show that Gpr17, an orphan GPCR, is co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent...

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Detalles Bibliográficos
Autores principales: Yan, Shijun, Conley, Jason M., Reilly, Austin M., Stull, Natalie D., Abhyankar, Surabhi D., Ericsson, Aaron C., Kono, Tatsuyoshi, Molosh, Andrei I., Kubal, Chandrashekhar A., Evans-Molina, Carmella, Ren, Hongxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972502/
https://www.ncbi.nlm.nih.gov/pubmed/34986353
http://dx.doi.org/10.1016/j.celrep.2021.110179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972502/
https://www.ncbi.nlm.nih.gov/pubmed/34986353
http://dx.doi.org/10.1016/j.celrep.2021.110179

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