The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes

In pluripotent cells, a delicate activation-repression balance maintains pro-differentiation genes ready for rapid activation. The identity of transcription factors (TFs) that specifically repress pro-differentiation genes remains obscure. By targeting ~1,700 TFs with CRISPR loss-of-function screen,...

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Detalles Bibliográficos
Autores principales: Garipler, Görkem, Lu, Congyi, Morrissey, Alexis, Lopez-Zepeda, Lorena S., Pei, Yingzhen, Vidal, Simon E., Fiore, Ana Paula Zen Petisco, Aydin, Begüm, Stadtfeld, Matthias, Ohler, Uwe, Mahony, Shaun, Sanjana, Neville E., Mazzoni, Esteban O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972945/
https://www.ncbi.nlm.nih.gov/pubmed/35294876
http://dx.doi.org/10.1016/j.celrep.2022.110524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972945/
https://www.ncbi.nlm.nih.gov/pubmed/35294876
http://dx.doi.org/10.1016/j.celrep.2022.110524

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