Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM

Immuno-PET is a powerful tool to noninvasively characterize the in vivo biodistribution of engineered antibodies. Methods: L1 cell adhesion molecule–targeting humanized (HuE71) IgG(1) and IgG(4) antibodies bearing identical variable heavy- and light-chain sequences but different fragment crystalliza...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, Sai Kiran, Suzuki, Maya, Xu, Hong, Korsen, Joshua A., Samuels, Zachary, Guo, Hongfen, Nemieboka, Brandon, Piersigilli, Alessandra, Edwards, Kimberly J., Cheung, Nai-Kong V., Lewis, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2022
Materias:
Basic Science Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973293/
https://www.ncbi.nlm.nih.gov/pubmed/34353869
http://dx.doi.org/10.2967/jnumed.121.262383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973293/
https://www.ncbi.nlm.nih.gov/pubmed/34353869
http://dx.doi.org/10.2967/jnumed.121.262383

Ejemplares similares