Cytoplasmic DROSHA and Non-canonical Mechanisms of MiR-155 Biogenesis in FLT3-ITD Acute Myeloid Leukemia

We report here on a novel pro-leukemogenic role of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) that interferes with microRNAs (miRNAs) biogenesis in acute myeloid leukemia (AML) blasts. We showed that FLT3-ITD interferes with the canonical biogenesis of intron-hosted miRNAs lik...

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Detalles Bibliográficos
Autores principales: Nguyen, Le Xuan Truong, Zhang, Bin, Hoang, Dinh Hoa, Zhao, Dandan, Wang, Huafeng, Wu, Herman, Su, Yu-Lin, Dong, Haojie, Rodriguez-Rodriguez, Sonia, Armstrong, Brian, Ghoda, Lucy Y., Perrotti, Danilo, Pichiorri, Flavia, Chen, Jianjun, Li, Ling, Kortylewski, Marcin, Rockne, Russell C., Kuo, Ya-Huei, Khaled, Samer, Carlesso, Nadia, Marcucci, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973317/
https://www.ncbi.nlm.nih.gov/pubmed/33589748
http://dx.doi.org/10.1038/s41375-021-01166-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973317/
https://www.ncbi.nlm.nih.gov/pubmed/33589748
http://dx.doi.org/10.1038/s41375-021-01166-9

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