Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase

Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT inhibitors are believed to be a potential platform f...

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Detalles Bibliográficos
Autores principales: Małolepsza, Joanna, Marchwicka, Aleksandra, Serwa, Remigiusz A., Niinivehmas, Sanna P., Pentikäinen, Olli T., Gendaszewska-Darmach, Edyta, Błażewska, Katarzyna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973367/
https://www.ncbi.nlm.nih.gov/pubmed/35354390
http://dx.doi.org/10.1080/14756366.2022.2053525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973367/
https://www.ncbi.nlm.nih.gov/pubmed/35354390
http://dx.doi.org/10.1080/14756366.2022.2053525

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