Biodegradable and biocompatible subcutaneous implants consisted of pH-sensitive mebendazole-loaded/folic acid-targeted chitosan nanoparticles for murine triple-negative breast cancer treatment

BACKGROUND: Mebendazole (MBZ) is a well-known anti-parasite drug with significant anti-cancer properties. However, MBZ exhibits low solubility, limited absorption efficacy, extensive first-pass effect, and low bioavailability. Therefore, multiple oral administration of high dose MBZ is required dail...

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Detalles Bibliográficos
Autores principales: Kefayat, Amirhosein, Hosseini, Maryam, Ghahremani, Fatemeh, Jolfaie, Nafise Arbab, Rafienia, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973744/
https://www.ncbi.nlm.nih.gov/pubmed/35361226
http://dx.doi.org/10.1186/s12951-022-01380-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973744/
https://www.ncbi.nlm.nih.gov/pubmed/35361226
http://dx.doi.org/10.1186/s12951-022-01380-2

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