Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model

Hypoxia-inducible factor 1 α (Hif1α) plays a crucial role in brain development. To study the function of Hif1α in early brain development, we generated neuroepithelial cell-specific Hif1α-knockout mice. Hif1α-knockout mice died soon after birth; these mice exhibited an abnormal head shape, indicatin...

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Detalles Bibliográficos
Autores principales: Sakai, Daisuke, Sugawara, Takeru, Kurokawa, Tomonori, Murakami, Yuki, Tomosugi, Mitsuhiro, Masuta, Hiroko, Sakata-Haga, Hiromi, Hatta, Toshihisa, Shoji, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973788/
https://www.ncbi.nlm.nih.gov/pubmed/35361248
http://dx.doi.org/10.1186/s13041-022-00911-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973788/
https://www.ncbi.nlm.nih.gov/pubmed/35361248
http://dx.doi.org/10.1186/s13041-022-00911-0

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