Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors

BACKGROUND: PI3K signaling is frequently activated in breast cancer and is targeted by PI3K inhibitors. However, resistance of tumor cells to PI3K inhibition, often mediated by activated receptor tyrosine kinases, is commonly observed and reduces the potency of PI3K inhibitors. Therefore, new treatm...

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Detalles Bibliográficos
Autores principales: Heynen, Guus J. J. E., Lisek, Kamil, Vogel, Regina, Wulf-Goldenberg, Annika, Alcaniz, Joshua, Montaudon, Elodie, Marangoni, Elisabetta, Birchmeier, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974145/
https://www.ncbi.nlm.nih.gov/pubmed/35365185
http://dx.doi.org/10.1186/s13058-022-01521-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974145/
https://www.ncbi.nlm.nih.gov/pubmed/35365185
http://dx.doi.org/10.1186/s13058-022-01521-3

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