4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress

Rifampin (RFP), a first-line anti-tuberculosis drug, often induces cholestatic liver injury and hyperbilirubinemia which limits its clinical use. Multidrug resistance-associated protein 2 (MRP2) localizes to the hepatocyte apical membrane and plays a pivotal role in the biliary excretion of bilirubi...

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Detalles Bibliográficos
Autores principales: Chen, Jing, Wu, Hongbo, Tang, Xudong, Chen, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974152/
https://www.ncbi.nlm.nih.gov/pubmed/35045794
http://dx.doi.org/10.1080/21655979.2021.2024970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974152/
https://www.ncbi.nlm.nih.gov/pubmed/35045794
http://dx.doi.org/10.1080/21655979.2021.2024970

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