Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3

Osteoarthritis (OA) affects approximately 12% of the aging Western population. The sirtuin/forkhead box O (SIRT/FOXO) signaling pathway plays essential roles in various biological processes. Despite it has been demonstrated that ubiquitin-specific protease 3 (USP3) inhibits chondrocyte apoptosis ind...

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Detalles Bibliográficos
Autores principales: Zhou, Qi, Wang, Wei, Wu, Jun, Qiu, Shang, Yuan, Shuai, Fu, Pei-Liang, Qian, Qi-Rong, Xu, Yao-Zeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974216/
https://www.ncbi.nlm.nih.gov/pubmed/34847835
http://dx.doi.org/10.1080/21655979.2021.2012552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974216/
https://www.ncbi.nlm.nih.gov/pubmed/34847835
http://dx.doi.org/10.1080/21655979.2021.2012552

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