Cargando…

The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma

A small population of self-renewing stem cells initiate tumors and maintain therapeutic resistance in glioblastoma (GBM). Given the limited treatment options and dismal prognosis for this disease, there is urgent need to identify drivers of stem cells that could be druggable targets. Previous work s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ko, Myungjun, Makena, Monish R, Schiapparelli, Paula, Suarez-Meade, Paola, Mekile, Allatah X, Lal, Bachchu, Lopez-Bertoni, Hernando, Kozielski, Kristen L, Green, Jordan J, Laterra, John, Quiñones-Hinojosa, Alfredo, Rao, Rajini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974362/ https://www.ncbi.nlm.nih.gov/pubmed/35387234 http://dx.doi.org/10.1093/pnasnexus/pgac013

Ejemplares similares

Secretory pathway Ca(2+)-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry
por: Makena, Monish Ram, et al.
Publicado: (2022)

Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells
por: Makena, Monish Ram, et al.
Publicado: (2021)

Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
por: Schwede, M, et al.
Publicado: (2014)

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151()()
por: Tilghman, Jessica, et al.
Publicado: (2016)

Endosomal pH in neuronal signaling and synaptic transmission: role of Na(+)/H(+) exchanger NHE5
por: Diering, Graham H., et al.
Publicado: (2014)

The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and Function
por: Lawrence, Scott P., et al.
Publicado: (2010)

Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth
por: Zhan, Daqian, et al.
Publicado: (2021)

Endosomal Na(+)/H(+) exchanger NHE5 influences MET recycling and cell migration
por: Fan, Steven Hung-Yi, et al.
Publicado: (2016)

Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
por: Lucien, Fabrice, et al.
Publicado: (2017)

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons
por: Fernandez, Marty A., et al.
Publicado: (2022)

FUNCTIONAL EVALUATION OF AUTISM-ASSOCIATED MUTATIONS IN NHE9
por: Kondapalli, Kalyan C., et al.
Publicado: (2013)

A Leak Pathway for Luminal Protons in Endosomes Drives Oncogenic Signaling in Glioblastoma
por: Kondapalli, Kalyan C., et al.
Publicado: (2015)

The cancer stem cell phenotype: You can't win until you learn how to lose it
por: Lopez-Bertoni, Hernando, et al.
Publicado: (2015)

Opinion: miRNAs – The new wave of molecular cancer therapeutics
por: Lopez-Bertoni, Hernando, et al.
Publicado: (2021)

Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
por: Lopez-Bertoni, Hernando, et al.
Publicado: (2022)

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
por: Fernandez-Gil, Beatriz I., et al.
Publicado: (2022)

Cancer Stem Cells: Dynamic Entities in an Ever-Evolving Paradigm
por: Lopez-Bertoni, Hernando, et al.
Publicado: (2014)

SYST-12 LP-184, A NOVEL ACYLFULVENE-DERIVED TUMOR SITE ACTIVATED SMALL MOLECULE INHIBITS ADULT AND PEDIATRIC CNS TUMOR CELL GROWTH
por: Kulkarni, Aditya, et al.
Publicado: (2023)

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity
por: Sun, Peng, et al.
Publicado: (2014)

Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunities
por: Johnson, Amanda L., et al.
Publicado: (2022)

Propranolol suppresses bladder cancer by manipulating intracellular pH via NHE1
por: Hu, Qian, et al.
Publicado: (2022)

Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na(+)/H(+) exchanger NHE3 by glucocorticoids
por: He, Peijian, et al.
Publicado: (2011)

The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance
Publicado: (1995)

Complex Formation between NheB and NheC Is Necessary to Induce Cytotoxic Activity by the Three-Component Bacillus cereus Nhe Enterotoxin
por: Heilkenbrinker, Uta, et al.
Publicado: (2013)

Structure of the NheA Component of the Nhe Toxin from Bacillus cereus: Implications for Function
por: Ganash, Magdah, et al.
Publicado: (2013)

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase
por: Wang, Shervin D., et al.
Publicado: (2012)

Role of NHE1 in Nociception
por: Torres-López, Jorge Elías, et al.
Publicado: (2013)

Targeting endosomal pH for cancer chemotherapy
por: Lucien, Fabrice, et al.
Publicado: (2018)

Large Population Analysis of Secondary Cancers in Pediatric Leukemia Survivors
por: Yavvari, Siddhartha, et al.
Publicado: (2019)

Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway
por: Kucharava, Krystsina, et al.
Publicado: (2020)

Loss of Christianson Syndrome Na(+)/H(+) Exchanger 6 (NHE6) Causes Abnormal Endosome Maturation and Trafficking Underlying Lysosome Dysfunction in Neurons
por: Pescosolido, Matthew F., et al.
Publicado: (2021)

A WICB 50th Favorite: Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature
por: Quiñones-Frías, Mónica C.
Publicado: (2021)

Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes
por: Sarker, Rafiquel, et al.
Publicado: (2017)

Cellular microenvironment modulates the galvanotaxis of brain tumor initiating cells
por: Huang, Yu-Ja, et al.
Publicado: (2016)

Engineering Three-Dimensional Tumor Models to Study Glioma Cancer Stem Cells and Tumor Microenvironment
por: Ruiz-Garcia, Henry, et al.
Publicado: (2020)

Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration
por: Oyinlade, Olutobi, et al.
Publicado: (2018)

DDRE-33. MELATONIN AS A MASTER METABOLIC SWITCH FOR GLIOBLASTOMA
por: Fernandez-Gil, Beatriz Irene, et al.
Publicado: (2021)

The Na(+)/H(+) Exchanger NHE6 in the Endosomal Recycling System Is Involved in the Development of Apical Bile Canalicular Surface Domains in HepG2 Cells
por: Ohgaki, Ryuichi, et al.
Publicado: (2010)

Endosomal acidification by Na(+)/H(+) exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling
por: Diering, Graham H., et al.
Publicado: (2013)

Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function
por: Jung, Seung-Won, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hadoe8sd48chi9m6neg598tmhq