CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function

Adoptive transfer of genetically modified or donor-derived T cells can efficiently eradicate human tumors but is also frequently associated with major toxicity. There are several switches that can be used to kill the infused cell pool in the case of major toxicity, but the irreversible nature of the...

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Detalles Bibliográficos
Autores principales: Sahillioglu, Ali Can, Toebes, Mireille, Apriamashvili, Georgi, Gomez, Raquel, Schumacher, Ton N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Priority Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974419/
https://www.ncbi.nlm.nih.gov/pubmed/34193461
http://dx.doi.org/10.1158/2326-6066.CIR-21-0095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974419/
https://www.ncbi.nlm.nih.gov/pubmed/34193461
http://dx.doi.org/10.1158/2326-6066.CIR-21-0095

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