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CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function
Adoptive transfer of genetically modified or donor-derived T cells can efficiently eradicate human tumors but is also frequently associated with major toxicity. There are several switches that can be used to kill the infused cell pool in the case of major toxicity, but the irreversible nature of the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for Cancer Research
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974419/ https://www.ncbi.nlm.nih.gov/pubmed/34193461 http://dx.doi.org/10.1158/2326-6066.CIR-21-0095 |