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Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations

Asthma affects more than 300 million people globally and is both under diagnosed and under treated. The most recent and largest genome-wide association study investigating moderate to severe asthma to date was carried out in 2019 and identified 25 independent signals. However, as new and in-depth do...

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Detalles Bibliográficos
Autores principales: Portelli, Michael A., Rakkar, Kamini, Hu, Sile, Guo, Yike, Adcock, Ian M., Sayers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974692/
https://www.ncbi.nlm.nih.gov/pubmed/35386986
http://dx.doi.org/10.3389/falgy.2021.738741