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Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities

The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cells, mast cells, basophils, ILC2s, and epithelial c...

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Detalles Bibliográficos
Autores principales: Smeekens, Johanna M., Kulis, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974753/
https://www.ncbi.nlm.nih.gov/pubmed/35387036
http://dx.doi.org/10.3389/falgy.2021.810067
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author Smeekens, Johanna M.
Kulis, Michael D.
author_facet Smeekens, Johanna M.
Kulis, Michael D.
author_sort Smeekens, Johanna M.
collection PubMed
description The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cells, mast cells, basophils, ILC2s, and epithelial cells. Mouse models of food allergy mimic the overall immunologic processes known to exist in humans. Due to the limitations of invasive sampling of human tissue and the similarities of the human and mouse immune systems, comprehensive pathogenesis studies of food allergy have been performed in mouse models. Mouse models have been effective in elucidating the roles of non-oral routes of sensitization and identifying key cells and molecules involved in allergic sensitization. Furthermore, the development of novel therapeutic approaches for food allergy has been accelerated through the use of pre-clinical mouse models. Despite the groundbreaking findings stemming from research in mice, there are continued efforts to improve the translational utility of these models. Here, we highlight the achievements in understanding food allergy development and efforts to bring novel treatment approaches into clinical trials.
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spelling pubmed-89747532022-04-05 Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities Smeekens, Johanna M. Kulis, Michael D. Front Allergy Allergy The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cells, mast cells, basophils, ILC2s, and epithelial cells. Mouse models of food allergy mimic the overall immunologic processes known to exist in humans. Due to the limitations of invasive sampling of human tissue and the similarities of the human and mouse immune systems, comprehensive pathogenesis studies of food allergy have been performed in mouse models. Mouse models have been effective in elucidating the roles of non-oral routes of sensitization and identifying key cells and molecules involved in allergic sensitization. Furthermore, the development of novel therapeutic approaches for food allergy has been accelerated through the use of pre-clinical mouse models. Despite the groundbreaking findings stemming from research in mice, there are continued efforts to improve the translational utility of these models. Here, we highlight the achievements in understanding food allergy development and efforts to bring novel treatment approaches into clinical trials. Frontiers Media S.A. 2021-12-15 /pmc/articles/PMC8974753/ /pubmed/35387036 http://dx.doi.org/10.3389/falgy.2021.810067 Text en Copyright © 2021 Smeekens and Kulis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Allergy
Smeekens, Johanna M.
Kulis, Michael D.
Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
title Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
title_full Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
title_fullStr Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
title_full_unstemmed Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
title_short Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
title_sort mouse models of food allergy in the pursuit of novel treatment modalities
topic Allergy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974753/
https://www.ncbi.nlm.nih.gov/pubmed/35387036
http://dx.doi.org/10.3389/falgy.2021.810067
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