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Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities
The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cells, mast cells, basophils, ILC2s, and epithelial c...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974753/ https://www.ncbi.nlm.nih.gov/pubmed/35387036 http://dx.doi.org/10.3389/falgy.2021.810067 |
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author | Smeekens, Johanna M. Kulis, Michael D. |
author_facet | Smeekens, Johanna M. Kulis, Michael D. |
author_sort | Smeekens, Johanna M. |
collection | PubMed |
description | The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cells, mast cells, basophils, ILC2s, and epithelial cells. Mouse models of food allergy mimic the overall immunologic processes known to exist in humans. Due to the limitations of invasive sampling of human tissue and the similarities of the human and mouse immune systems, comprehensive pathogenesis studies of food allergy have been performed in mouse models. Mouse models have been effective in elucidating the roles of non-oral routes of sensitization and identifying key cells and molecules involved in allergic sensitization. Furthermore, the development of novel therapeutic approaches for food allergy has been accelerated through the use of pre-clinical mouse models. Despite the groundbreaking findings stemming from research in mice, there are continued efforts to improve the translational utility of these models. Here, we highlight the achievements in understanding food allergy development and efforts to bring novel treatment approaches into clinical trials. |
format | Online Article Text |
id | pubmed-8974753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89747532022-04-05 Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities Smeekens, Johanna M. Kulis, Michael D. Front Allergy Allergy The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cells, mast cells, basophils, ILC2s, and epithelial cells. Mouse models of food allergy mimic the overall immunologic processes known to exist in humans. Due to the limitations of invasive sampling of human tissue and the similarities of the human and mouse immune systems, comprehensive pathogenesis studies of food allergy have been performed in mouse models. Mouse models have been effective in elucidating the roles of non-oral routes of sensitization and identifying key cells and molecules involved in allergic sensitization. Furthermore, the development of novel therapeutic approaches for food allergy has been accelerated through the use of pre-clinical mouse models. Despite the groundbreaking findings stemming from research in mice, there are continued efforts to improve the translational utility of these models. Here, we highlight the achievements in understanding food allergy development and efforts to bring novel treatment approaches into clinical trials. Frontiers Media S.A. 2021-12-15 /pmc/articles/PMC8974753/ /pubmed/35387036 http://dx.doi.org/10.3389/falgy.2021.810067 Text en Copyright © 2021 Smeekens and Kulis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Allergy Smeekens, Johanna M. Kulis, Michael D. Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities |
title | Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities |
title_full | Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities |
title_fullStr | Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities |
title_full_unstemmed | Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities |
title_short | Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities |
title_sort | mouse models of food allergy in the pursuit of novel treatment modalities |
topic | Allergy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974753/ https://www.ncbi.nlm.nih.gov/pubmed/35387036 http://dx.doi.org/10.3389/falgy.2021.810067 |
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