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Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort

More than 40% of the germline variants in ClinVar today are variants of uncertain significance (VUSs). These variants remain unclassified in part because the patient-level data needed for their interpretation is siloed. Federated analysis can overcome this problem by “bringing the code to the data”:...

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Detalles Bibliográficos
Autores principales:	Casaletto, James, Parsons, Michael, Markello, Charles, Iwasaki, Yusuke, Momozawa, Yukihide, Spurdle, Amanda B., Cline, Melissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Technology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975122/ https://www.ncbi.nlm.nih.gov/pubmed/35373174 http://dx.doi.org/10.1016/j.xgen.2022.100109

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