USP1-trapping lesions as a source of DNA replication stress and genomic instability

The deubiquitinase USP1 is a critical regulator of genome integrity through the deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor, proliferating cell nuclear antigen (PCNA). Uniquely, following UV irradiation, USP1 self-inactivates through autocleavage, which en...

Descripción completa

Detalles Bibliográficos
Autores principales: Coleman, Kate E., Yin, Yandong, Lui, Sarah Kit Leng, Keegan, Sarah, Fenyo, David, Smith, Duncan J., Rothenberg, Eli, Huang, Tony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975806/
https://www.ncbi.nlm.nih.gov/pubmed/35365626
http://dx.doi.org/10.1038/s41467-022-29369-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975806/
https://www.ncbi.nlm.nih.gov/pubmed/35365626
http://dx.doi.org/10.1038/s41467-022-29369-3

Ejemplares similares