Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness

Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1 (SMARCA4) subunit of the...

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Detalles Bibliográficos
Autores principales: Schiavoni, Federica, Zuazua-Villar, Pedro, Roumeliotis, Theodoros I., Benstead-Hume, Graeme, Pardo, Mercedes, Pearl, Frances M. G., Choudhary, Jyoti S., Downs, Jessica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975814/
https://www.ncbi.nlm.nih.gov/pubmed/35365638
http://dx.doi.org/10.1038/s41467-022-29420-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975814/
https://www.ncbi.nlm.nih.gov/pubmed/35365638
http://dx.doi.org/10.1038/s41467-022-29420-3

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