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Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness
Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context dependent. The BRG1 (SMARCA4) subunit of the...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975814/ https://www.ncbi.nlm.nih.gov/pubmed/35365638 http://dx.doi.org/10.1038/s41467-022-29420-3 |