Cargando…

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation

Myeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimulate angiogenesis, immune suppression and tumor progression. Chemokines, cytokines and i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmid, Michael C., Kang, Sang Won, Chen, Hui, Paradise, Marc, Ghebremedhin, Anghesom, Kaneda, Megan M., Chin, Shao-Ming, Do, Anh, Watterson, D. Martin, Varner, Judith A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975949/ https://www.ncbi.nlm.nih.gov/pubmed/35365657 http://dx.doi.org/10.1038/s41467-022-29471-6

Ejemplares similares

PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth
por: Schmid, Michael C., et al.
Publicado: (2013)

Myeloid cells in tumor inflammation
por: Schmid, Michael C, et al.
Publicado: (2012)

Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation
por: Schmid, Michael C., et al.
Publicado: (2010)

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
por: Morin, Nicole A., et al.
Publicado: (2008)

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
por: Morin, Nicole A., et al.
Publicado: (2008)

Association of Epstein - Barr virus and breast cancer in Eritrea
por: Fessahaye, Ghimja, et al.
Publicado: (2017)

Myosin light chain kinase and myosin light chain phosphatase from Dictyostelium: effects of reversible phosphorylation on myosin structure and function
Publicado: (1987)

Angiotensin II, a unique vasoactive agent dissociates myosin light chain phosphorylation from contraction
por: HIRANO, Takashi, et al.
Publicado: (2017)

Neonatal and adult myosin heavy chains form homodimers during avian skeletal muscle development
Publicado: (1991)

Assembly of avian skeletal muscle myosins: evidence that homodimers of the heavy chain subunit are the thermodynamically stable form
Publicado: (1991)

Critical Role of Non-Muscle Myosin Light Chain Kinase in Thrombin-Induced Endothelial Cell Inflammation and Lung PMN Infiltration
por: Fazal, Fabeha, et al.
Publicado: (2013)

Effects of Myosin “Essential” Light Chain A1 on the Aggregation Properties of the Myosin Head
por: Markov, D.I., et al.
Publicado: (2010)

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2015)

Synthesis of rat myosin light chains in heterokaryons formed between undifferentiated rat myoblasts and chick skeletal myocytes
Publicado: (1981)

Identification of a new mechanism for targeting myosin II heavy chain phosphorylation by Dictyostelium myosin heavy chain kinase B
por: Underwood, Julie, et al.
Publicado: (2010)

Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis
por: Feng, Zhonghui, et al.
Publicado: (2015)

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
por: Alieva, N. O., et al.
Publicado: (2019)

Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development
Publicado: (1996)

Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin
por: Hitsumoto, Tatsuro, et al.
Publicado: (2023)

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I
por: Sevrieva, Ivanka R., et al.
Publicado: (2020)

Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemomechanical properties despite bearing the same myosin heavy chain isoform
por: Wang, Tianbang, et al.
Publicado: (2022)

Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains
por: Kollmar, Martin
Publicado: (2006)

Synthesis of myosin heavy and light chains in muscle cultures
Publicado: (1975)

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia
por: Braun, David J., et al.
Publicado: (2019)

Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase
por: Xu, Zhili, et al.
Publicado: (2017)

Myosin II-Mediated Focal Adhesion Maturation Is Tension Insensitive
por: Stricker, Jonathan, et al.
Publicado: (2013)

Caenorhabditis elegans Unc-45 Is a Component of Muscle Thick Filaments and Colocalizes with Myosin Heavy Chain B, but Not Myosin Heavy Chain a
por: Ao, Wanyuan, et al.
Publicado: (2000)

Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
por: Choi, Cheolwon, et al.
Publicado: (2016)

Laminin-332 γ2 Monomeric Chain Promotes Adhesion and Migration of Hepatocellular Carcinoma Cells
por: Scialpi, Rosanna, et al.
Publicado: (2023)

Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle
por: Hong, Feng, et al.
Publicado: (2015)

Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis
por: Taneja, Nilay, et al.
Publicado: (2021)

Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules
por: Osten, Jennifer, et al.
Publicado: (2022)

An unconventional myosin heavy chain gene from Drosophila melanogaster
Publicado: (1992)

Myosin light-chain expression during avian muscle development
por: Crow, MT, et al.
Publicado: (1983)

Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation
por: Mills, Jason C., et al.
Publicado: (1998)

Myosin Heavy Chains IIa and IId Are Functionally Distinct in the Mouse
por: Sartorius, Carol A., et al.
Publicado: (1998)

Hybrids of Physarum myosin light chains and desensitized scallop myofibrils
Publicado: (1981)

Skeletal myosin heavy chain function in cultured lung myofibroblasts
por: Rice, Nancy A., et al.
Publicado: (2003)

Characteristics of light chains of Chara myosin revealed by immunological investigation
por: KAKEI, Toshihito, et al.
Publicado: (2012)

Dynamic Regulation of Myosin Light Chain Phosphorylation by Rho-kinase
por: Kaneko-Kawano, Takako, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_splrurk1hu3dbqfft7tf5on7lt