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A benzodiazepine activator locks K(v)7.1 channels open by electro-mechanical uncoupling
Loss-of-function mutations in K(v)7.1 often lead to long QT syndrome (LQTS), a cardiac repolarization disorder associated with arrhythmia and subsequent sudden cardiac death. The discovery of agonistic I(Ks) modulators may offer a new potential strategy in pharmacological treatment of this disorder....
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976019/ https://www.ncbi.nlm.nih.gov/pubmed/35365746 http://dx.doi.org/10.1038/s42003-022-03229-8 |