A benzodiazepine activator locks K(v)7.1 channels open by electro-mechanical uncoupling

Loss-of-function mutations in K(v)7.1 often lead to long QT syndrome (LQTS), a cardiac repolarization disorder associated with arrhythmia and subsequent sudden cardiac death. The discovery of agonistic I(Ks) modulators may offer a new potential strategy in pharmacological treatment of this disorder....

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Detalles Bibliográficos
Autores principales: Schreiber, Julian A., Möller, Melina, Zaydman, Mark, Zhao, Lu, Beller, Zachary, Becker, Sebastian, Ritter, Nadine, Hou, Panpan, Shi, Jingyi, Silva, Jon, Wrobel, Eva, Strutz-Seebohm, Nathalie, Decher, Niels, Schmitt, Nicole, Meuth, Sven G., Düfer, Martina, Wünsch, Bernhard, Cui, Jianmin, Seebohm, Guiscard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976019/
https://www.ncbi.nlm.nih.gov/pubmed/35365746
http://dx.doi.org/10.1038/s42003-022-03229-8

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