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Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors

BACKGROUND: Glyoxalase system is one of the defense cellular mechanisms that protect cells against endogenous harmful metabolites, mainly methylglyoxal (MG), through conversion of cytotoxic methylglyoxal into the non-toxic lactic acid. Glyoxalase system comprises of two enzymes glyoxalase I, glyoxal...

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Detalles Bibliográficos
Autores principales: Audat, Suaad Abdallah, Al-Balas, Qosay Ali, Al-Oudat, Buthina Abdallah, Athamneh, Mo’ad Jamil, Bryant-Friedrich, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976160/
https://www.ncbi.nlm.nih.gov/pubmed/35378924
http://dx.doi.org/10.2147/DDDT.S356621