The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials

Background: Higher serum homocysteine is associated with cognitive decline in older people. But homocysteine-lowering trials including folic acid (FA) show inconsistent results on cognitive decline. The reduction of FA to dihydrofolate by dihydrofolate reductase (DHFR) is slow in humans. Objective:...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yuanyuan, Smith, A David, Bastani, Nasser E, Refsum, Helga, Kwok, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976423/
https://www.ncbi.nlm.nih.gov/pubmed/34788822
http://dx.doi.org/10.1093/hmg/ddab246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976423/
https://www.ncbi.nlm.nih.gov/pubmed/34788822
http://dx.doi.org/10.1093/hmg/ddab246

Ejemplares similares