PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity

It is critical to understand the molecular mechanisms governing the regulation of MITF, a lineage specific transcription factor in melanocytes and an oncogene in melanoma. We identified PPP6C, a serine/threonine phosphatase, as a key regulator of MITF in melanoma. PPP6C is the only recurrently mutat...

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Detalles Bibliográficos
Autores principales: Maskin, Carolyn R., Raman, Renuka, Houvras, Yariv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976846/
https://www.ncbi.nlm.nih.gov/pubmed/35368039
http://dx.doi.org/10.1038/s41598-022-08936-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976846/
https://www.ncbi.nlm.nih.gov/pubmed/35368039
http://dx.doi.org/10.1038/s41598-022-08936-0

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