Lipid-driven CFTR clustering is impaired in cystic fibrosis and restored by corrector drugs

Membrane proteins often cluster in nanoscale membrane domains (lipid rafts) that coalesce into ceramide-rich platforms during cell stress, however the clustering mechanisms remain uncertain. The cystic fibrosis transmembrane conductance regulator (CFTR), which is mutated in cystic fibrosis (CF), for...

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Detalles Bibliográficos
Autores principales: Abu-Arish, Asmahan, Pandžić, Elvis, Luo, Yishan, Sato, Yukiko, Turner, Mark J., Wiseman, Paul W., Hanrahan, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976878/
https://www.ncbi.nlm.nih.gov/pubmed/35060604
http://dx.doi.org/10.1242/jcs.259002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976878/
https://www.ncbi.nlm.nih.gov/pubmed/35060604
http://dx.doi.org/10.1242/jcs.259002

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