Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics

Tumourigenesis and cancer progression require enhanced global protein translation(1–3). Such enhanced translation is caused by oncogenic and tumour suppressive events that drive the synthesis and activity of translational machinery(4,5). Here we report the surprising observation that leucyl-tRNA syn...

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Detalles Bibliográficos
Autores principales: Passarelli, Maria C., Pinzaru, Alexandra M., Asgharian, Hosseinali, Liberti, Maria V., Heissel, Søren, Molina, Henrik, Goodarzi, Hani, Tavazoie, Sohail F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977047/
https://www.ncbi.nlm.nih.gov/pubmed/35288656
http://dx.doi.org/10.1038/s41556-022-00856-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977047/
https://www.ncbi.nlm.nih.gov/pubmed/35288656
http://dx.doi.org/10.1038/s41556-022-00856-5

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