Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors

Kinases play key roles in signaling networks that are activated by G-protein-coupled receptors (GPCRs). Kinase activities are generally inferred from cell lysates, hiding cell-to-cell variability. To study the dynamics and heterogeneity of ERK and Akt proteins, we employed high-content biosensor ima...

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Detalles Bibliográficos
Autores principales: Chavez-Abiega, Sergei, Grönloh, Max L. B., Gadella, Theodorus W. J., Bruggeman, Frank J., Goedhart, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Tools and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977056/
https://www.ncbi.nlm.nih.gov/pubmed/35107584
http://dx.doi.org/10.1242/jcs.259685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977056/
https://www.ncbi.nlm.nih.gov/pubmed/35107584
http://dx.doi.org/10.1242/jcs.259685

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