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Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors
Kinases play key roles in signaling networks that are activated by G-protein-coupled receptors (GPCRs). Kinase activities are generally inferred from cell lysates, hiding cell-to-cell variability. To study the dynamics and heterogeneity of ERK and Akt proteins, we employed high-content biosensor ima...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977056/ https://www.ncbi.nlm.nih.gov/pubmed/35107584 http://dx.doi.org/10.1242/jcs.259685 |