Cargando…
The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the evolutionarily conserved CMGC protein kinase superfamily. Due to its localization on chromosome 21, the biological significance of DYRK1A...
Autores principales: | Rammohan, Malini, Harris, Ethan, Bhansali, Rahul S., Zhao, Emily, Li, Loretta S., Crispino, John D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977259/ https://www.ncbi.nlm.nih.gov/pubmed/35220406 http://dx.doi.org/10.1038/s41388-022-02245-6 |
Ejemplares similares
-
Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A
por: Fruit, Corinne, et al.
Publicado: (2019) -
The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer
por: Friedman, Eileen
Publicado: (2010) -
The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
por: Boni, Jacopo, et al.
Publicado: (2020) -
Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control
por: Singh, Rajeev, et al.
Publicado: (2017) -
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3
por: Thompson, Benjamin J., et al.
Publicado: (2015)