Targeted protein degradation: mechanisms, strategies and application

Traditional drug discovery mainly focuses on direct regulation of protein activity. The development and application of protein activity modulators, particularly inhibitors, has been the mainstream in drug development. In recent years, PROteolysis TArgeting Chimeras (PROTAC) technology has emerged as...

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Detalles Bibliográficos
Autores principales: Zhao, Lin, Zhao, Jia, Zhong, Kunhong, Tong, Aiping, Jia, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977435/
https://www.ncbi.nlm.nih.gov/pubmed/35379777
http://dx.doi.org/10.1038/s41392-022-00966-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977435/
https://www.ncbi.nlm.nih.gov/pubmed/35379777
http://dx.doi.org/10.1038/s41392-022-00966-4

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