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m(6)A demethylase ALKBH5 drives denervation‐induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling

BACKGROUND: Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment of primary neuropathies, it is a clinical condition that should be investigated. FoxO3 activation is an indispensable mechanism in denervation‐induced...

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Detalles Bibliográficos
Autores principales: Liu, Yuantong, Zhou, Tianjian, Wang, Qinghe, Fu, Runhan, Zhang, Zengfu, Chen, Nandi, Li, Zhizhong, Gao, Guoyong, Peng, Songlin, Yang, Dazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978003/
https://www.ncbi.nlm.nih.gov/pubmed/35142084
http://dx.doi.org/10.1002/jcsm.12929