LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity

Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC–MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in red blood cells (RBCs). This method utilizes a...

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Detalles Bibliográficos
Autores principales: Bajaj, Amol O., Kushnir, Mark M., Kish-Trier, Erik, Law, Rachel N., Zuromski, Lauren M., Molinelli, Alejandro R., McMillin, Gwendolyn A., Johnson-Davis, Kamisha L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978547/
https://www.ncbi.nlm.nih.gov/pubmed/35387339
http://dx.doi.org/10.3389/fphar.2022.836812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978547/
https://www.ncbi.nlm.nih.gov/pubmed/35387339
http://dx.doi.org/10.3389/fphar.2022.836812

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