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LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity
Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC–MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in red blood cells (RBCs). This method utilizes a...
Autores principales: | Bajaj, Amol O., Kushnir, Mark M., Kish-Trier, Erik, Law, Rachel N., Zuromski, Lauren M., Molinelli, Alejandro R., McMillin, Gwendolyn A., Johnson-Davis, Kamisha L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978547/ https://www.ncbi.nlm.nih.gov/pubmed/35387339 http://dx.doi.org/10.3389/fphar.2022.836812 |
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