Cargando…

Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study

BACKGROUND: Steroid-dependent asthma (SDA) is characterized by oral corticosteroid (OCS) resistance and dependence. Wumeiwan (WMW) showed potentials in reducing the dose of OCS of SDA patients based on our previous studies. METHODS: Network pharmacology was conducted to explore the molecular mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyu, Mingsheng, Wang, Yahui, Chen, Qiuyi, Qin, Jingbo, Hou, Dan, Huang, Shuaiyang, Shao, Dongmei, Gong, Xuefeng, Huang, Guirui, Zhang, Shiyu, Zhang, Zhijie, Cui, Hongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978578/ https://www.ncbi.nlm.nih.gov/pubmed/35386850 http://dx.doi.org/10.2147/DDDT.S349950

Ejemplares similares

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study
por: Lyu, Mingsheng, et al.
Publicado: (2023)

Corrigendum: Effect of M6A regulators on diagnosis, subtype classification, prognosis and novel therapeutic target development of idiopathic pulmonary fibrosis
por: Huang, Guirui, et al.
Publicado: (2022)

Effect of M6A regulators on diagnosis, subtype classification, prognosis and novel therapeutic target development of idiopathic pulmonary fibrosis
por: Huang, Guirui, et al.
Publicado: (2022)

Molecular docking, network pharmacology and experimental verification to explore the mechanism of Wulongzhiyangwan in the treatment of pruritus
por: Anqi, Lyu, et al.
Publicado: (2023)

Deciphering the mechanisms of Yinlan Tiaozhi capsule in treating hyperlipidemia by combining network pharmacology, molecular docking and experimental verification
por: Xiao, Guanlin, et al.
Publicado: (2023)

Study on the molecular mechanisms of tetrandrine against pulmonary fibrosis based on network pharmacology, molecular docking and experimental verification
por: Li, Jie, et al.
Publicado: (2022)

Investigation on the Mechanisms of Zanthoxylum bungeanum for Treating Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Experiment Verification
por: Huang, Yuanshe, et al.
Publicado: (2023)

Exploration of the mechanism of luteolin against ischemic stroke based on network pharmacology, molecular docking and experimental verification
por: Dong, Rui, et al.
Publicado: (2021)

A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification
por: Zhang, Jingyuan, et al.
Publicado: (2020)

Combining network pharmacology, molecular docking, molecular dynamics simulation, and experimental verification to examine the efficacy and immunoregulation mechanism of FHB granules on vitiligo
por: Li, Xiaolong, et al.
Publicado: (2023)

Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis
por: Yang, Bowen, et al.
Publicado: (2022)

Molecular mechanism of Ganji Fang in the treatment of hepatocellular carcinoma based on network pharmacology, molecular docking and experimental verification technology
por: Yang, Miaolun, et al.
Publicado: (2023)

Exploring the Therapeutic Mechanisms of Huzhang–Shanzha Herb Pair against Coronary Heart Disease by Network Pharmacology and Molecular Docking
por: Li, Dan, et al.
Publicado: (2021)

Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer
por: Kai, Kang, et al.
Publicado: (2023)

Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification
por: Zhu, Xiling, et al.
Publicado: (2023)

Analysis of the Mechanism of GuizhiFuling Wan in Treating Adenomyosis Based on Network Pharmacology Combined with Molecular Docking and Experimental Verification
por: Shi, Yaxin, et al.
Publicado: (2022)

Potential Molecular Target Prediction and Docking Verification of Hua-Feng-Dan in Stroke Based on Network Pharmacology
por: Yang, Ping, et al.
Publicado: (2020)

Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification
por: Zhu, Yingyin, et al.
Publicado: (2021)

Identification and verification of effective components of Huanghuai for dysfunctional uterine bleeding based on network pharmacology and molecular docking
por: Yao, Yun-xiu, et al.
Publicado: (2020)

Exploring the Mechanism of Wenshen Huatan Quyu Decotion for PCOS Based on Network Pharmacology and Molecular Docking Verification
por: Guo, Xin, et al.
Publicado: (2022)

Exploring the Mechanism of Chuanxiong Rhizoma against Thrombosis Based on Network Pharmacology, Molecular Docking and Experimental Verification
por: He, Shasha, et al.
Publicado: (2023)

Development of Novel Herbal Compound Formulations Targeting Neuroinflammation: Network Pharmacology, Molecular Docking, and Experimental Verification
por: Liu, Yang, et al.
Publicado: (2023)

Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification
por: Fang, Pingfei, et al.
Publicado: (2022)

Exploring the molecular mechanism of Gan Shuang granules for the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking, and experimental verification
por: Zhi, Guoguo, et al.
Publicado: (2023)

Molecular Mechanism of the Therapeutic Effect of Peach Blossom against Constipation: An Exploratory Study Based on Network Pharmacology Analysis and Molecular Docking Verification
por: Ma, Bo, et al.
Publicado: (2023)

The mechanism of TiaoGanYiPi formula for treating chronic hepatitis B by network pharmacology and molecular docking verification
por: Cao, Xu, et al.
Publicado: (2021)

Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification
por: Xu, Lin, et al.
Publicado: (2021)

Uncovering the Mechanism of Curcuma in the Treatment of Ulcerative Colitis Based on Network Pharmacology, Molecular Docking Technology, and Experiment Verification
por: Liu, Suxian, et al.
Publicado: (2021)

The potential mechanism of Bletilla striata in the treatment of ulcerative colitis determined through network pharmacology, molecular docking, and in vivo experimental verification
por: Gong, Shanshan, et al.
Publicado: (2022)

Network Pharmacology Analysis, Molecular Docking, and In Vitro Verification Reveal the Action Mechanism of Prunella vulgaris L. in Treating Breast Cancer
por: Bai, Haotian, et al.
Publicado: (2022)

Identifying molecular targets of Aspiletrein-derived steroidal saponins in lung cancer using network pharmacology and molecular docking-based assessments
por: Iksen, Iksen, et al.
Publicado: (2023)

Mechanism of Action of Yin Nourishing and Heat Clearing Prescription in Treating Cough Variant Asthma Based on Network Pharmacology and Molecular Docking Verification
por: Zhang, Yin, et al.
Publicado: (2022)

Network pharmacology, molecular docking, and experimental verification reveal the mechanism of San-Huang decoction in treating acute kidney injury
por: Liu, Jiahui, et al.
Publicado: (2023)

Rapid identification of α-glucosidase inhibitors from Poria using spectrum-effect, component knock-out, and molecular docking technique
por: Ma, Changyang, et al.
Publicado: (2023)

Insight into the orientational versatility of steroid substrates—a docking and molecular dynamics study of a steroid receptor and steroid monooxygenase
por: Panek, Anna, et al.
Publicado: (2017)

Investigation of the Underlying Mechanism of Huangqi-Dangshen for Myasthenia Gravis Treatment via Molecular Docking and Network Pharmacology
por: Liu, Miao, et al.
Publicado: (2023)

Network pharmacological prediction and molecular docking analysis of the combination of Atractylodes macrocephala Koidz. and Paeonia lactiflora Pall. in the treatment of functional constipation and its verification
por: Meng, Yuxiao, et al.
Publicado: (2022)

A Bioinformatics Research on Novel Mechanism of Compound Kushen Injection for Treating Breast Cancer by Network Pharmacology and Molecular Docking Verification
por: Liu, Shuyu, et al.
Publicado: (2020)

Exploring the mechanism by which aqueous Gynura divaricata inhibits diabetic foot based on network pharmacology, molecular docking and experimental verification
por: Sun, Yu, et al.
Publicado: (2023)

Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma
por: Mir, Wajahat Rashid, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a71ur4c06vkhhr1jpl7cmn1nt3