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Conjugation with gold nanoparticles improves the stability of the KT2 peptide and maintains its anticancer properties

One of the major weaknesses of therapeutic peptides is their sensitivity to degradation by proteolytic enzymes in vivo. Gold nanoparticles (GNPs) are a good carrier for therapeutic peptides to improve their stability and cellular uptake in vitro and in vivo. We conjugated the anticancer KT2 peptide...

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Detalles Bibliográficos
Autores principales: Maraming, Pornsuda, Daduang, Jureerut, Kah, James Chen Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978663/
https://www.ncbi.nlm.nih.gov/pubmed/35424498
http://dx.doi.org/10.1039/d1ra05980g