Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors

Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 inhibitors. Herein, we report a simple continuo...

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Detalles Bibliográficos
Autores principales: Sthalam, Vinay Kumar, Mahajan, Bhushan, Karra, Purushotham Reddy, Singh, Ajay K., Pabbaraja, Srihari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978682/
https://www.ncbi.nlm.nih.gov/pubmed/35424481
http://dx.doi.org/10.1039/d1ra08220e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978682/
https://www.ncbi.nlm.nih.gov/pubmed/35424481
http://dx.doi.org/10.1039/d1ra08220e

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