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Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection

Emerging evidence suggests that people with alcohol use disorders are at higher risk for SARS-CoV-2. SARS-CoV-2 engages angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors for cellular entry. While ACE2 and TMPRSS2 genes are upregulated in the cortex of alc...

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Detalles Bibliográficos
Autores principales: Balasubramanian, Nagalakshmi, James, Thomas D, Pushpavathi, Selvakumar Govindhasamy, Marcinkiewcz, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978936/
https://www.ncbi.nlm.nih.gov/pubmed/35378747
http://dx.doi.org/10.1101/2022.03.29.486282