Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats

Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration of Mrp2 leads to conjugated hyperbilirubinemia and predisposes to the development of intrahepatic cholestasis of pregnancy (ICP), characterized by increased plasma b...

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Detalles Bibliográficos
Autores principales: Alaei Faradonbeh, Fatemeh, Lastuvkova, Hana, Cermanova, Jolana, Hroch, Milos, Nova, Zuzana, Uher, Martin, Hirsova, Petra, Pavek, Petr, Micuda, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979289/
https://www.ncbi.nlm.nih.gov/pubmed/35388287
http://dx.doi.org/10.3389/fphys.2022.859294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979289/
https://www.ncbi.nlm.nih.gov/pubmed/35388287
http://dx.doi.org/10.3389/fphys.2022.859294

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